Alternative Coenzyme Q10

Note
Integrative therapies should not replace antiretroviral therapy (ART) in HIV patients. Patients should consult their healthcare providers before taking any herbs or supplements because they may interact with treatment. In particular, patients should not take St. John’s wort because it may interact with HIV treatment.

Unclear or conflicting scientific evidence

Coenzyme Q10

Coenzyme Q10 (CoQ10) is produced by the body and it is necessary for basic functioning of cells. CoQ10 levels decrease with age. There is limited evidence that natural levels of CoQ10 in the body may be reduced in people with HIV/AIDS.

Reliable scientific research showing that CoQ10 supplements have any effect on this disease is currently lacking.

There are currently no documented cases of allergy associated with Coenzyme Q10 supplements, although rash and itching have rarely been reported.

  1. Stop use two weeks before surgery/dental/diagnostic procedures with bleeding risk and do not use immediately after these procedures.
  2. Use cautiously with history of blood clots, diabetes, high blood pressure, heart attack, or stroke.
  3. Use cautiously with anticoagulants (blood thinners), anti-platelet drugs, blood pressure drugs, blood sugar drugs,cholesterol drugs, or thyroid drugs.
  4. Avoid if pregnant or breast feeding.

Selected References
AIDS.org. www.aids.org. Accessed March 29, 2009.
American Foundation for AIDS Research (amfAR). www.amfar.org. Accessed March 29, 2009.
Centers for Disease Control and Prevention (CDC). www.cdc.gov. Accessed March 29, 2009.
Elizabeth Glaser Pediatric AIDS Foundation. www.pedaids.org. Accessed March 29, 2009.
Halperin DT, Steiner MJ, Cassell MM, et al. The time has come for common ground on preventing sexual transmission of HIV.Lancet. 2004 Nov 27-Dec 3;364(9449):1913-5.
Loutfy MR, Antoniou T, Shen S, et al. Virologic and immunologic impact and durability of enfuvirtide-based antiretroviraltherapy in HIV-infected treatment-experienced patients in a clinical setting. HIV Clin Trials. 2007Jan-Feb;8(1):36-44.
National Institute of Allergy and Infectious Diseases (NIAD). www.niaid.nih.gov. Accessed March 29, 2009.
Natural Standard: The Authority on Integrative Medicine. www.naturalstandard.com. Copyright © 2009. Accessed March 29, 2009.
Rigopoulos D, Gregoriou S, Paparizos V, et al. AIDS in pregnancy, part II: Treatment in the era of highly active antiretroviral therapy and management of obstetric, anesthetic, and pediatric issues. Skinmed. 2007 Mar-Apr;6(2):79-84.
The Body: The Complete HIV/AIDS Resource. www.thebody.com. Accessed March 29, 2009.
U.S. Food and Drug Administration (FDA). www.fda.gov. Accessed March 29, 2009.
Vrouenraets SM, Wit FW, van Tongeren J, et al. Efavirenz: a review. Expert Opin Pharmacother. 2007 Apr;8(6):851-71.